When we use empathy and human-centered approaches in developing health interventions, we have the capacity to affect social change. We can direct human-centered computing toward underserved populations. We can target marginalization, stigma, and inequity with human- centered methods. In this talk, I will share projects that have focused on addressing inequities within children’s behavioral health services, treatment for youth living with HIV, and opioid overdose prevention. I will present methodological approaches to designing for and with underserved populations, and show how to practice inclusion and equity in the design process. Based on the results of my projects, I will also outline design principles for health information technologies that do not sacrifice humanity for standardization. Finally, I will discuss the importance of broadening participation in computing, for more equitable research participation, methods, and output.