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Dynamical systems biology: from dynamics to mechanisms in cell regulation
Jordi Garcia-Ojalvo - Universitat Pompeu Fabra
Tuesday, October 8, 2013, 12:00-1:00 pm Calendar
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Abstract

Cellular processes rely on the coordinated dynamical activity of multiple
genes and proteins linked together in regulatory circuits. Understanding
cellular processes requires a global view of these circuits at the system
level. In that scenario, theoretical models are necessary in order to
comprehend cellular behavior. Since the experimental values of most model
parameters are unknown, it is imperative to validate the models by performing
a quantitative comparison between experiments and theory. Here we show how
such a comparison can be undertaken in a systematic way, using bacterial
stress response as a case example. Examples will be discussed ranging from
signal integration by single cells to spatial organization of bacterial
biofilms. Our results show how dynamics plays a crucial role in allowing
for a quantitative approach to cell physiology.

This talk is organized by Mihai Pop