Trapped atomic ions are a leading platform for quantum information networks, with long-lived identical qubit memories that can be locally entangled through their Coulomb interaction and remotely entangled through photonic channels. However, performing both local and remote operations in a single node of a quantum network requires extreme isolation between spectator qubit memories and qubits associated with the photonic interface. We achieve this isolation by cotrapping 171Yb+ and 138Ba+ qubits. We further demonstrate the ingredients of a scalable ion trap network node with two distinct experiments that consist of entangling the mixed species qubit pair through their collective motion and entangling a 138Ba+ qubit with an emitted visible photon.