Many people are frustrated and concerned with how corporations, intelligence agencies, and other adversarial actors harvest their personal data. Yet most feel powerless to protect themselves or effect change. How might we design computing systems that empower people with greater agency over their personal data? In this talk, I will describe my research exploring three interdisciplinary, human-centered approaches to address this question. First, my lab is working with material scientists and electrical engineers to develop smart physical barriers that provide physical privacy guarantees against intrusive ambient sensors in IoT and edge computing devices. I will describe our design and evaluation of a Smart Webcam Cover (UbiComp’22) that uses physical world signals to automatically obfuscate laptop webcams when users do not intend them to be in use. Second, we are working with legal scholars to design systems that facilitate grassroots privacy collective action to protest intrusive institutional personal data practices. I will describe results from a deployment of our design probe, Unified Voice (CHI’22), that employs crowd programming patterns to shepherd collectives in generating and converging on concrete demands for redress in the wake of institutional privacy violations. Third, we are working with human-centered AI and design researchers to develop Privacy through Design: a design methodology to help practitioners model the trade-offs between utility and intrusiveness in competing consumer AI design concepts. I will describe our work on assessing the utility versus intrusiveness of Dynamic Audience Selection (CSCW’21) on Facebook: a design concept that allows users to use natural language to articulate who should and should not be able to see their posts. My work presages a future in which well-meaning technologists and end-users can exert leverage over the institutions and adversarial actors that seek to harvest their personal data.